Amygdalin alleviates MAFLD via inhibiting cytoplasmic calcium ion overload-induced liver sinusoidal endothelial cell defenestration - PubMed
8 hours ago
- #Liver Sinusoidal Endothelial Cells
- #Amygdalin
- #MAFLD
- Amygdalin (Amy) is a key component of Semen Persicae that alleviates MAFLD in mice by targeting liver sinusoidal endothelial cells (LSECs).
- Amy treatment reduces hepatic steatosis and inflammation, improving metabolic parameters and restoring LSEC fenestration density disrupted in MAFLD.
- The mechanism involves Amy inhibiting excessive endoplasmic reticulum Ca²⁺ release by lowering PGE2 and IP3 levels, thus reversing cytoplasmic Ca²⁺ overload in LSECs.