Endoplasmic Reticulum Stress in the Keratinocytes Contributes to Chronic Itch by Activation of Lipocalin 2/MC4R/TRPV1 Pathway - PubMed
5 hours ago
- #Chronic itch
- #Endoplasmic reticulum stress
- #Keratinocytes
- Endoplasmic reticulum (ER) stress in keratinocytes contributes to chronic itch.
- ER stress inhibitor 4-PBA reduces itch-related behaviors in mouse models.
- Lipocalin-2 (LCN2) levels are elevated in affected skin and plasma under chronic itch conditions.
- LCN2 induces hyperexcitability in dorsal root ganglia neurons via MC4R and TRPV1 pathways.
- Inhibition of ER stress in keratinocytes could be a therapeutic strategy for chronic itch.