FXR overexpression promotes liver regeneration through inducing FGF2 activation in APAP-induced acute liver injury - PubMed
6 hours ago
- #liver regeneration
- #FXR signaling
- #APAP toxicity
- FXR expression is significantly reduced in liver tissues of patients with APAP-induced acute liver injury.
- Overexpression of FXR in mice mitigates APAP-induced liver damage by reducing inflammation, oxidative stress, and apoptosis.
- FXR promotes liver regeneration, which is dependent on the upregulation of FGF2.
- Knockdown of either FXR or FGF2 reverses the protective and regenerative effects.
- The study suggests FXR as a potential therapeutic target for APAP-induced acute liver injury.