Therapeutic effects of mesenchymal stem cells and their secretomes (extracellular vesicles) with bone-implant scaffolds for bone regeneration: A systematic review and network meta-analysis of preclini
17 days ago
- #bone regeneration
- #mesenchymal stem cells
- #extracellular vesicles
- Mesenchymal stem cells (MSCs) and extracellular vesicles (EVs) combined with bone-regenerative scaffolds enhance healing of critical-size bone defects.
- Bone marrow MSCs (BMSCs) outperform adipose-derived MSCs (ADSCs) in bone regeneration, with BMSC-derived EVs further improving outcomes.
- Multi-component composite scaffolds show the highest potential for new bone formation among cell-free designs.
- Calvarial defect models demonstrate greater bone regeneration gains compared to long-bone models.
- The study highlights the need for standardized protocols and core outcome sets due to heterogeneity in models, biomaterials, and dosing.