LRP8 is a functional receptor for yellow fever virus - PubMed
3 hours ago
- #Pathogenesis
- #Viral Receptor
- #Yellow Fever Virus
- LRP8 identified as a functional receptor for yellow fever virus (YFV).
- LRP8 expression enhances YFV infection in cell lines by promoting viral entry.
- Human LRP8 expression in mouse liver worsens infection and pathology from clinical YFV strain BJ01.
- LRP8 knockdown reduces YFV infection in brain cells, primary human hepatocytes, and mosquitoes.
- LRP8 interacts directly with YFV 17D particles via the viral envelope protein.
- A soluble LRP8 decoy protein can inhibit infection by YFV 17D and BJ01 strains.
- Findings offer insights into YFV entry mechanisms, tropism, and pathogenesis.