Diabetes-associated MYT1 and ST18 genes regulate human beta cell insulin secretion and survival via other diabetes risk genes - PubMed
4 hours ago
- #Diabetes
- #Beta Cell
- #Genetic Regulation
- MYT1 knockdown in human beta cells causes cell death, while ST18 knockdown impairs glucose-stimulated insulin secretion.
- Under obesity-induced stress, ST18 knockdown also leads to beta cell death.
- MYT1 knockdown deregulates genes related to cell death and stress response, while ST18 knockdown affects genes regulating stress response, mitochondria, and ion channels.
- ST18 knockdown reduces glucose-stimulated Ca2+ influx in beta cells.
- MYT1- and ST18-regulated genes are enriched for type 2 diabetes-associated loci, showing a 2.05-fold enrichment compared to random beta cell-expressed genes.
- The MYT transcription factors integrate genetic and environmental factors to prevent beta cell failure and type 2 diabetes, mainly by influencing beta cell viability and Ca2+ influx.