Influence of USP15 and its derived-peptide on non-small cell lung cancer immune evasion via regulating PD-L1 stability - PubMed
21 hours ago
- #PD-L1
- #immune evasion
- #USP15
- USP15 acts as a deubiquitinase that stabilizes PD-L1 by inhibiting its ubiquitination and degradation in NSCLC cells.
- USP15 promotes NSCLC immune evasion by reducing CD8+ T cell population and activation in the tumor microenvironment.
- A derived peptide U10 disrupts USP15-PD-L1 interaction, degrades PD-L1, and suppresses NSCLC immune escape.
- U10 enhances the anti-NSCLC effect of PD-1 monoclonal antibody in mouse models.
- USP15 and PD-L1 expression levels are higher in NSCLC tissues and positively correlated, predicting immunotherapy efficacy and prognosis.