ITGA5 as a Dual Regulator of Epithelial-Mesenchymal Transition and Epithelial Cell Anoikis Resistance: Functional Validation and Drug Prediction - PubMed
5 hours ago
- #Anoikis Resistance
- #ITGA5
- #Epithelial-Mesenchymal Transition
- ITGA5 is significantly upregulated in asthma patients, HDM-sensitized asthma mice, and TGF-β1-induced EMT models.
- Elevated ITGA5 expression correlates with reduced lung function, asthma severity, and higher levels of EMT regulators (Fibronectin, N-cadherin, Vimentin).
- ITGA5 promotes mesenchymal transition via the PI3K/Akt pathway and negatively regulates anoikis.
- ITGA5 knockdown reverses TGF-β1-induced EMT, inhibits PI3K/Akt pathway activation, and restores anoikis sensitivity.
- Resveratrol (Res) and M200 are identified as potential ITGA5 inhibitors, reducing EMT and anoikis resistance in asthma mice.
- The study suggests ITGA5-targeted therapy as a promising approach for attenuating airway remodeling in asthma.