Circulating tumor DNA in breast cancer: From technological foundation to clinical implementation - PubMed
3 days ago
- #Liquid Biopsy
- #Precision Medicine
- #Breast Cancer
- Circulating tumor DNA (ctDNA) is a non-invasive tool for breast cancer management.
- ctDNA captures genetic and epigenetic alterations like mutations and methylation patterns.
- Applications include early screening, treatment response evaluation, and resistance tracking.
- Technological advances in PCR, NGS, and biosensors improve detection sensitivity.
- Challenges include assay standardization, detection variability, and high costs.
- Future focus: technological refinement, multi-omics integration, and large-scale trials.