Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory - PubMed
5 hours ago
- #Immunology
- #T cells
- #Metabolism
- Metabolic quiescence in naive-like memory T cells is crucial for long-term immunological memory.
- Human CD8+ T cells use glycolysis for proliferation and oxidative phosphorylation for energy during acute immune responses.
- CD8+CD62L+CD45RA- central memory T cells are the most metabolically active subset post-vaccination.
- CD8+CD62L-CD45RA+ effector T cells undergo metabolic shutdown after the acute phase.
- Naive-like memory T cells (CD8+CD62L+CD45RA+CD95-) rely solely on oxidative phosphorylation and are maintained long-term.
- The study highlights the link between cellular quiescence and longevity in immunological memory.