Antigen-boosted CD4 CAR-T cells fail to expand or control viremia in multiple nonhuman primate models of HIV - PubMed
5 hours ago
- #gene therapy
- #CAR-T cells
- #HIV
- Antigen-boosted CD4 CAR-T cells failed to expand or control viremia in nonhuman primate models of HIV.
- Multiple strategies were tested to enhance CD4 CAR-T cell efficacy, including CRISPR-Cas9 gene editing and exogenous antigen boosting.
- Despite ex vivo antigen-specific proliferation and cytotoxicity, CD4 CAR-T cells did not expand or persist in vivo.
- Previous observations of CD4 CAR-T cell expansions could not be confirmed and will be retracted.
- The study highlights the need for alternative strategies to improve anti-HIV CD4 CAR-T cell therapy.