Can cord blood unit selection improve outcomes after single-unit unrelated cord blood transplantation for non-remission acute myeloid leukemia? - PubMed
6 hours ago
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- Cord blood unit selection can impact outcomes in single-unit unrelated cord blood transplantation (CBT) for non-remission acute myeloid leukemia (AML).
- Higher CD34+ cell doses (≥0.608 × 10^5/kg) are associated with decreased overall mortality.
- Female-to-male donor-recipient sex incompatibility increases mortality, while male-to-female reduces it.
- HLA serologic compatibility (0 mismatches) increases relapse risk but lowers non-relapse mortality (NRM).
- HLA allele-level compatibility (0-1 mismatches) increases relapse risk, while ≥5 mismatches raise NRM.
- Higher CD34+ cell and CFU-GM doses accelerate hematopoietic recovery but may increase chronic GVHD risk.
- Optimal graft selection must balance engraftment and disease control for non-remission AML.