DRP1 and MID49 co-diffusion scans mitochondria for fission - PubMed
5 hours ago
- #organelle division
- #mitochondrial fission
- #DRP1 dynamics
- DRP1 oligomers diffuse in helical-like trajectories along mitochondria, scanning the surface and stalling at preconstricted fission sites in a 'mito-scanner' motion.
- Perturbation of DRP1 motility results in elongated mitochondria, highlighting its functional importance in mitochondrial division.
- DRP1 dynamics on mitochondria are regulated by interactions with adaptors like MID49/MID51, with co-diffusion promoting DRP1 motility.
- Molecular dynamics simulations support a geometry-mediated diffusion mechanism due to surface confinement.
- The model suggests receptor-regulated mitochondrial surveillance by DRP1 enables balanced organelle division, with potential implications for disease targeting.