Variation in SNX29 and Acute Vasodilator Response in Pulmonary Arterial Hypertension - PubMed
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- #SNX29 gene
- #vasodilator response
- #pulmonary arterial hypertension
- Variation in SNX29 gene influences acute vasodilator response in pulmonary arterial hypertension (PAH).
- Genetic analysis identified rs8057488 in SNX29 as significant, linked to hemodynamic changes after vasodilator use.
- SNX29 affects store-operated calcium entry and endosomal trafficking in pulmonary artery smooth muscle cells.
- In vivo studies show SNX29 overexpression reduces hypoxic vasoconstriction, suggesting a role in vasodilation.