Celastrol disrupts the inflammatory feedback loop driven by Tenascin-C⁺ fibroblast subtype in psoriasis: Insights from single-cell RNA sequencing and experimental validation - PubMed
5 hours ago
- #Psoriasis
- #Inflammation
- #Celastrol
- Celastrol, a natural compound, shows therapeutic potential in psoriasis by disrupting inflammatory feedback loops.
- Single-cell RNA sequencing identified a TNC�� fibroblast subtype driving inflammation in psoriasis.
- TNC�� fibroblasts secrete chemokines and cytokines, activating TNF-NF-κB and IL-6-JAK-STAT3 pathways.
- Celastrol disrupts the inflammatory loop by suppressing key proteins, alleviating psoriasis-like symptoms in mice.
- The study provides new insights into celastrol's multi-target mechanism and clinical potential for psoriasis treatment.