Interferon signaling gene expression, and DNA methylation interactions in Sjögren's disease via mendelian randomization - PubMed
7 hours ago
- #DNA methylation
- #Interferon signaling
- #Sjögren's disease
- Sjögren's disease (SD) is an autoimmune disorder with dysregulated interferon (IFN) signaling.
- Study integrated transcriptomic, epigenomic, and genetic data using Mendelian randomization (SMR) and colocalization analyses.
- Meta-analysis identified 331 differentially expressed IFN-associated genes enriched in immune cells.
- SMR analysis identified five causal genes: SH2B3, LGALS9, CD40, GRB2, and DTX3L.
- DNA methylation at specific CpG sites regulated SH2B3 and LGALS9 expression.
- Colocalization showed interaction with inflammatory cytokines like CCL19, IL-2Rβ, IL-10, and CCL4.
- ELISA validation confirmed elevated serum levels of these cytokines in SD patients.
- Study highlights epigenetic regulation of IFN-associated genes and potential therapeutic targets.