Multifunctional copper-based nanoparticles potentiate colorectal cancer immunotherapy via synergistic metabolic remodeling and cGAS-STING pathway activation - PubMed
3 days ago
- #immunotherapy
- #colorectal-cancer
- #nanoparticles
- Multifunctional copper-based nanoparticles (BR@CuM@CM) enhance colorectal cancer immunotherapy by targeting metabolic and immune pathways.
- BR@CuM@CM combines STING agonist SR-717 and glycolysis inhibitor 3-BP for synergistic tumor microenvironment modulation.
- The nanoparticle achieves tumor-specific accumulation and releases drugs in response to glutathione, activating STING and generating ROS.
- 3-BP inhibits lactate production, repolarizing macrophages to M1 phenotype and reducing Treg infiltration, enhancing immune response.
- Combined with anti-PD-1, BR@CuM@CM significantly inhibits tumor growth and metastasis, converting 'cold' tumors to 'hot'.