Clonal Hematopoiesis and Its Cardiovascular Implications: A Scientific Statement From the American Heart Association - PubMed
3 months ago
- #Cardiovascular Disease
- #Inflammation
- #Clonal Hematopoiesis
- Clonal hematopoiesis (CH) is the benign clonal expansion of hematopoietic stem cells, often caused by somatic mutations linked to hematologic malignancies.
- CH has been identified as a risk factor for various cardiovascular diseases (CVDs), including atherosclerosis, heart failure, atrial fibrillation, and thrombosis.
- The cardiovascular risk associated with CH varies based on specific genes, clone size, and external factors.
- CH contributes to CVDs through gene-specific pathways and broader inflammatory processes, such as aberrant cytokine production and inflammasome activation.
- CH is primarily age-related but can be influenced by germline predispositions, obesity, chronic inflammation, and environmental toxins like tobacco or certain cancer treatments.
- Incorporating CH-associated risk into CVD prediction models could enable personalized preventive or therapeutic approaches.
- No CH-specific therapies currently exist for CVD treatment or prevention, but molecular-based therapeutic hypotheses are being tested.