Prussian blue analogue-mineralized ginseng-derived vesicles promote PPARγ nuclear translocation to suppress tumor vasculogenic mimicry and reverse the immunosuppressive microenvironment - PubMed
5 hours ago
- #immunotherapy
- #nanomedicine
- #cancer therapy
- Prussian blue analogue-mineralized ginseng-derived vesicles (GDVs@CuPBA-iRGD) suppress tumor vasculogenic mimicry (VM) and reverse the immunosuppressive microenvironment.
- GDVs@CuPBA-iRGD promotes PPARγ nuclear translocation, downregulating VM-associated genes and disrupting ECM remodeling.
- The nanoplatform exhibits pH-responsive degradation, enabling controlled drug release in the tumor microenvironment.
- In vitro and in vivo studies show GDVs@CuPBA-iRGD inhibits hepatocellular carcinoma (HCC) cell viability, invasion, and VM formation while inducing cuproptosis and ferroptosis.
- Single-cell RNA sequencing indicates VM suppression by GDVs@CuPBA-iRGD activates antitumor immunity.
- The study highlights a bioinspired, synergistic therapeutic strategy for VM-dependent aggressive tumors.