Dual regulatory roles of CPT1C in chronic stress-induced depression-related outcomes - PubMed
5 hours ago
- #depression
- #neuroscience
- #CPT1C
- CPT1C plays dual regulatory roles in chronic stress-induced depression-related outcomes.
- Enhanced GluA1 depalmitoylation in the nucleus accumbens mediates depressive-like behaviors after chronic stress.
- CPT1C dysfunction, a depalmitoylating enzyme for GluA1, contributes to depression-like behaviors in mice.
- D2-MSN-specific knockdown of CPT1C prevents stress-induced depression-like behaviors.
- CPT1C deficiency in D1-MSN abolishes behavioral and synaptic plasticity changes caused by fluoxetine.
- CPT1C regulates GluA1 synthesis by disinhibiting mTORC1 signaling via targeting tuberous sclerosis complex 2.
- CPT1C is identified as a novel therapeutic target for major depressive disorder (MDD).