Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis - PubMed
6 hours ago
- #Exosome
- #Orthodontic tooth movement
- #Pyroptosis
- Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis.
- The study involves experiments approved by the Institutional Animal Care and Use Committee of Peking University, China.
- The authors declare no competing interests.
- The research is supported by multiple grants including those from the National Key Research and Development Program of China and the National Natural Science Foundation of China.
- References include studies on tissue mechanotransduction, biomechanical responses in orthodontic tooth movement, and immunorthodontics.