PEX19 restricts porcine deltacoronavirus replication through farnesylation-dependent and -independent mechanisms - PubMed
5 hours ago
- #antiviral mechanism
- #farnesylation modification
- #innate immunity
- PEX19 is identified as a novel host restriction factor against porcine deltacoronavirus (PDCoV).
- Overexpression of PEX19 inhibits PDCoV replication, while knockout enhances it.
- PEX19's anti-PDCoV effect largely depends on its farnesylation modification.
- PEX19 restricts PDCoV through three pathways: reducing cellular cholesterol (farnesylation-dependent), targeting viral nsp2 for degradation (farnesylation-dependent), and inducing interferon production (farnesylation-independent).
- Findings highlight PEX19's potential as a therapeutic target against PDCoV infection.