Molecular pathology of primary aldosteronism and hypercortisolism: Impact on adrenal surgery - PubMed
6 hours ago
- #endocrinology
- #molecular pathology
- #adrenal surgery
- Recent advances in molecular pathology have identified genetic causes of benign aldosterone- and cortisol-producing adrenal lesions.
- Primary aldosteronism (PA) involves genes encoding potassium and voltage-gated calcium channels, while hypercortisolism involves PRKACA, PRKAR1A, and ARMC5 genes.
- These insights guide precise, function-preserving surgeries like mini back scope adrenalectomy (MBSA), reducing morbidity and adrenal insufficiency risk.
- Postoperative pathological analysis helps assess hormone secretion and genetics, providing prognostic information and directing further therapy.
- Understanding molecular pathophysiology improves outcomes and expands adrenalectomy usage as morbidity and mortality risks are better recognized.