A single-cell time-series atlas of endothelial cell embryonic development - PubMed
5 days ago
- #single-cell atlas
- #endothelial cells
- #embryonic development
- A single-cell time-series atlas of endothelial cell (EC) embryonic development in mice was created, covering 26 time points and 8 organs.
- The study revealed the emergence timing and lineage trajectory of organ-specific ECs, along with organ-specific genes and pathways.
- Most ECs showed distinguishable organ specificity before late gestation, with organotypic EC-enriched genes linked to vascular function in those organs.
- Human and mouse pulmonary ECs underwent an evolutionarily conserved transcriptional transition.
- Endothelial-specific knockout of Casz1, a pulmonary EC-enriched transcription factor, led to impaired vascular growth and disturbed pulmonary endothelial organotypic differentiation.
- The study provides a comprehensive endothelial resource, uncovering fundamental principles of organ-specific EC differentiation and molecular mechanisms in lung-specific vascular development.