Direct Oral Anticoagulant Protein Targets and Risk of Cerebral Venous Thrombosis: A Mendelian Randomization Study - PubMed
5 days ago
- #Direct oral anticoagulants
- #Cerebral venous thrombosis
- #Mendelian randomization
- Study examines the causal influence of direct oral anticoagulant (DOAC) protein targets on cerebral venous thrombosis (CVT) risk using Mendelian randomization.
- Genetic proxies for thrombin, activated factor X (FXa), and factor XI (FXI) were analyzed in UK Biobank and FinnGen cohorts.
- Results show genetically lower levels of FXI, FXa, and thrombin are associated with reduced CVT risk.
- Findings suggest inhibition of these proteins by DOACs could be an effective therapeutic strategy for CVT.