Transdiagnostic mapping of brain structural abnormalities and network-constrained gray matter atrophy patterns across affective and psychotic disorders - PubMed
4 hours ago
- #neuroimaging
- #psychiatric disorders
- #transdiagnostic
- Transdiagnostic meta-analysis of gray matter volume (GMV) alterations across major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ).
- Common GMV reductions identified in medial prefrontal cortex and superior temporal gyrus across disorders.
- Disorder-specific patterns: MDD shows less atrophy in limbic/paralimbic and temporoparietal regions; SZ exhibits more pronounced reductions in these areas.
- Ventrolateral prefrontal cortex is a shared disease epicenter; precuneus is a common buffer across disorders.
- Network effects: visual and dorsal attention networks show buffering; limbic, frontoparietal, subcortical, and default mode networks concentrate epicenter effects.
- Findings suggest shared and unique network-constrained GM atrophy patterns, advancing precision diagnostics and therapeutic strategies.