Histone lactylation modification promotes docetaxel resistance and tumor progression through CNN1-Mediated autophagy and cell cycle arrest in Castration-resistant prostate cancer - PubMed
3 days ago
- #CNN1 autophagy
- #histone lactylation
- #docetaxel resistance
- Histone lactylation and high lactate are linked to docetaxel resistance and poor prognosis in castration-resistant prostate cancer (CRPC).
- DTX-resistant CRPC shows increased histone lactylation, especially at H3K18la and H4K12la sites.
- Blocking lactate production reduces DTX resistance, slows cell migration, causes cell cycle arrest, and boosts autophagy.
- CNN1 is a key target of histone lactylation; high CNN1 levels correlate with more lactylation and DTX resistance.
- Inhibiting CNN1 reverses the effects of lactate blockage on cell cycle and autophagy.
- In vivo, overexpressing CNN1 cancels out the tumor-suppressing effects of lactate inhibition.