Highly ordered clustering of TNFα and BAFF ligand-receptor-intracellular adaptor complexes on a lipid membrane - PubMed
5 hours ago
- #Immune regulation
- #TNF receptors
- #Membrane clustering
- High-resolution structures of TNFR1 and BAFFR clusters on lipid membranes were studied.
- TNFα-TNFR1 complexes form ordered trimer clusters on lipid membranes.
- A TNFR1 antagonist disrupts clusters without affecting ligand binding or trimerization.
- BAFF receptor-ligand complexes (BAFFR, TACI, BCMA) mainly form pentagonal trimer clusters.
- TRAF3 adaptor binding to BAFF-BAFFR changes cluster shape from pentagonal to hexagonal.
- BAFF mutations that impair BAFFR activation prevent cluster formation.
- Ligand-induced ordered clustering is essential for TNFR1 and BAFFR activation.