Granulin+ Macrophages Promote Lineage Plasticity in Prostate Cancer Through Paracrine Signaling Loops - PubMed
5 hours ago
- #prostate-cancer
- #lineage-plasticity
- #macrophage
- Granulin+ macrophages drive lineage plasticity in prostate cancer via GRN/TNFRSF1A interaction and NF-κB activation.
- Reciprocal signaling between tumor cells and macrophages via CSF1/CSF1R sustains lineage plasticity.
- GRN promotes epithelial-mesenchymal transition and enzalutamide resistance in patient-derived organoids.
- CSF1R inhibition in TRAMP models disrupts the GRN+ macrophage-tumor cell feedforward loop.
- Spatial mapping shows direct interactions between VIM+ tumor cells and GRN+ macrophages.
- Three novel stromal populations (DCN+ endothelial cells, CCL7+ fibroblasts, IFIT1+ neutrophils) linked to relapse.