USP10 Deubiquitinates MTX2 to Suppress cGAS-STING Signaling in MI - PubMed
3 days ago
- #cGAS-STING Pathway
- #Myocardial Infarction
- #Protein Ubiquitination
- USP10 expression is reduced in border zone (BZ) cardiomyocytes after myocardial infarction (MI), suggesting therapeutic potential.
- USP10 protects against cardiac injury by mitigating mitochondrial dysfunction and preventing mitochondrial DNA release, inhibiting cGAS-STING pathway activation.
- USP10 deubiquitinates MTX2, enhancing its stability; the K93 site on MTX2 is critical for this regulation.
- The MTX2-K93R mutation reverses the adverse effects of USP10 loss in MI.
- Targeting USP10 in BZ cardiomyocytes could be a therapeutic strategy to reduce MI-induced cardiac injury.