Antimicrobial Resistance: The Answers - PubMed
2 months ago
- #Antimicrobial Resistance
- #Therapeutic Innovations
- #Public Health
- Antimicrobial resistance (AMR) is a global public health crisis, linked to 5 million deaths in 2019 and projected to cause 10 million deaths annually by 2050.
- Regulatory and policy frameworks at local, national, and international levels are addressing AMR through surveillance, diagnostics, infection prevention, and antibiotic prescribing.
- Recent research focuses on novel therapeutic approaches, including new antibiotics, combination therapies, and repurposed drugs.
- Exploration of novel antimicrobial agents includes antimicrobial peptides, nanomaterials, and compounds from extreme and natural environments.
- Ethnopharmacology, such as antimicrobial effects of plants, spices, honey, and venoms, is being studied for potential AMR solutions.
- Innovative therapies under investigation include immunotherapy, bacteriophage therapy, antimicrobial photodynamic therapy (aPDT), and microbiome manipulation like faecal microbiota transplantation (FMT).
- Technological advancements like artificial intelligence, machine learning, and Organ-on-a-Chip devices are enhancing antimicrobial research and development.
- The World Health Organization highlights the role of vaccines in preventing AMR and reducing its burden.