Metabolic dysregulation: Its role in diabetes mellitus and cancers - PubMed
6 hours ago
- #Metabolic dysregulation
- #Diabetes and cancer
- #Tumor microenvironment
- Diabetes mellitus (DM) is a significant risk factor for certain cancers, including liver, pancreas, and endometrial cancers.
- Core metabolic disturbances like hyperinsulinemia, hyperglycemia, and inflammation promote tumorigenesis by dysregulating oncogenic pathways such as IGF-1 signaling and DNA damage repair.
- Key molecular integrators like p38 MAPK, Wnt/β-catenin, and the AGEs-RAGE axis mediate metabolic stress, giving tumor cells proliferative and invasive advantages.
- Repurposing antidiabetic drugs for cancer therapy faces challenges due to inconsistent clinical outcomes.
- Future research should utilize spatial analysis and omics technologies to understand how diabetic metabolites reshape the tumor microenvironment (TME).
- This approach is crucial for developing targeted strategies to reduce cancer risk and improve outcomes for DM patients with cancer.