Single-Cell Analysis of Chemotherapy-induced Remodeling Reveals CD276-driven Basal-like Chemoresistance in Pancreatic Cancer - PubMed

5 days ago

Single-cell RNA sequencing was used to analyze paired pre- and post-treatment tumor biopsies from 28 PDAC patients undergoing chemotherapy.
A chemoresistant niche was identified, consisting of SNCG+ basal-like tumor cells, SPP1+ tumor-associated macrophages, and exhausted T cells, prevalent in nonresponders.
CD276/B7-H3 was found to be a key regulator, promoting a chemoresistant basal-like state in tumor cells and inducing T cell exhaustion.
The study highlights CD276/B7-H3 as a promising therapeutic target to overcome chemotherapy resistance in PDAC.

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