Functional brain abnormalities of cognitive impairments in schizophrenia indicating higher integration of working memory than other domains - PubMed
5 hours ago
- #working memory
- #cognitive impairments
- #schizophrenia
- The study conducted a meta-analysis of cognitive task fMRI studies to identify brain functional alterations in schizophrenia patients compared to healthy controls.
- Brain dysfunctions in schizophrenia patients were mainly found within the default mode and subcortical networks.
- Distinct brain dysfunctions were identified for each cognitive domain defined by the MATRICS Consensus Cognitive Battery (MCCB).
- Working memory deficits showed the greatest convergence with overall brain changes in schizophrenia, indicating higher functional integration of working memory compared to other cognitive domains.
- Significant correlations were found between brain alterations and negative symptoms as well as years of education.
- The meta-analysis included 232 datasets with 5229 schizophrenia patients and 6132 healthy controls.