PKM2 Lactylation Promotes Colorectal Cancer Vasculogenic Mimicry and Bevacizumab Resistance by Facilitating FOSL1 Super-Enhancer Formation - PubMed
12 hours ago
- #colorectal cancer
- #bevacizumab resistance
- #PKM2 lactylation
- PKM2 lactylation at K206 by AARS1 promotes nuclear translocation and interaction with FOSL1.
- PKM2 lactylation facilitates FOSL1-dependent super-enhancer formation, driving colorectal cancer (CRC) vasculogenic mimicry (VM) and bevacizumab resistance.
- Inhibition of PKM2 lactylation disrupts VM and enhances bevacizumab efficacy in pre-clinical CRC models.
- Targeting PKM2 lactylation is proposed as a strategy to improve bevacizumab's anti-tumor activity in CRC.