Capsular polysaccharides of Acinetobacter baumannii modulate antimicrobial resistance and innate immune response - PubMed
6 hours ago
- #Immune response
- #Acinetobacter baumannii
- #Antimicrobial resistance
- Capsular polysaccharides (CPS) of Acinetobacter baumannii play a key role in antimicrobial resistance and immune response modulation.
- CPS-deficient mutants showed increased susceptibility to antibiotics like gentamicin, tetracycline, colistin, and SDS.
- In the absence of CPS, bacteria formed thicker biofilms, which were more resistant to colistin, chlorhexidine, and hydrogen peroxide but remained sensitive to tetracycline and SDS.
- CPS were crucial for resistance to photodynamic therapy induced by blue light and chlorophyllin.
- The galU gene, responsible for CPS production, was upregulated under antibiotic exposure, blue light, fetal bovine serum, and macrophage contact.
- CPS-deficient mutants and their outer membrane vesicles triggered a stronger pro-inflammatory response compared to wild-type bacteria.
- CPS induced caspase-3 activation and promoted pro-inflammatory cytokine expression, enhancing neutrophil chemotaxis.
- CPS not only mask virulence factors but also actively influence host immune responses and antimicrobial resistance.