Safety and Efficacy of Direct Oral Anticoagulants Versus Vitamin K Antagonists for Cerebrovascular Ischemic Outcomes in Non-Valvular Atrial Fibrillation: A Systematic Review and Meta-Analysis - PubMed
5 hours ago
- #Atrial Fibrillation
- #Stroke Prevention
- #Direct Oral Anticoagulants
- DOACs show superior efficacy in reducing recurrent cerebrovascular ischemic events (RR 0.83) compared to VKAs in non-valvular AF patients.
- DOACs are associated with a lower risk of major bleeding (RR 0.77) versus VKAs.
- All-cause mortality was similar between DOACs and VKAs, but sensitivity analysis favored DOACs (RR 0.79).
- The study supports DOACs as first-line anticoagulation for stroke prevention in non-valvular AF per current guidelines.
- Meta-analysis included 11 studies with 814,716 patients, following PRISMA 2020 guidelines.