Triptonide-mediated PTGS2 Inhibition Induces Autophagic Cell Death to Suppress the Progression of Triple-negative Breast Cancer and Epithelial Ovarian Cancer - PubMed
4 days ago
- #Autophagic Cell Death
- #PTGS2 Inhibition
- #Triptonide
- Triptonide (TN), derived from Tripterygium wilfordii, shows potent antitumor effects against triple-negative breast cancer (TNBC) and epithelial ovarian cancer (EOC).
- TN inhibits proliferation in TNBC and EOC cell lines, xenograft models, and patient-derived organoids.
- PTGS2 is identified as a direct target of TN, binding to His-207 and inducing proteasome degradation via E3 ubiquitin-protein ligase NEDD4.
- TN-induced PTGS2 downregulation inhibits the JAK/STAT3/c-Myc signaling axis, leading to suppressed tumor proliferation and autophagic cell death.
- TN presents a novel therapeutic mechanism for TNBC and EOC through targeted PTGS2 degradation.