Perioperative and Renal Outcomes After Nephrectomy in Patients Receiving Glucagon-Like Peptide-1 Receptor Agonists: A Pilot Study - PubMed
5 hours ago
- #GLP-1 Receptor Agonists
- #Perioperative Care
- #Nephrectomy Outcomes
- The study investigated perioperative outcomes in patients on GLP-1RAs undergoing nephrectomy, using a retrospective claims analysis from 2021 to 2025.
- After propensity matching 980 GLP-1RA users with 980 controls, GLP-1RA use was linked to lower 30-day hospital readmission rates (OR=0.72; p=0.011).
- At 90 days, GLP-1RA users had reduced venous thromboembolism (OR=0.62; p=0.035), readmission (OR=0.62; p<0.001), acute kidney injury (OR=0.76; p=0.031), and major adverse kidney events (MAKE) (OR=0.56; p=0.004).
- MAKE reduction was significant for both partial (OR=0.45; p=0.0024) and radical nephrectomy (OR=0.54; p=0.0014).
- The findings suggest preoperative GLP-1RA therapy may lower postoperative risks like AKI and readmissions without increasing gastrointestinal or respiratory morbidity.