The moderation and mediation roles of white matter insults in relationship of APOE ε4 genotype with Alzheimer's disease and related phenotypes: two longitudinal studies - PubMed
5 hours ago
- #Alzheimer's disease
- #APOE ε4
- #white matter hyperintensities
- APOE ε4 carriers have larger and faster-growing white matter hyperintensities (WMH), linking genetic risk to white matter damage.
- WMH both mediates and moderates the effects of APOE ε4, worsening cognitive decline, neurodegeneration, amyloid-β deposition, and increasing dementia risk.
- Neuroinflammatory and axonal injury pathways may biologically explain how WMH influences the relationship between APOE ε4 and Alzheimer's disease progression.