Regulation of Lipid Dysmetabolism and Neuroinflammation Progression Linked With Alzheimer's Disease Through Modulation of Dgat2 - PubMed
4 hours ago
- #Alzheimer's disease
- #lipid metabolism
- #neuroinflammation
- Alzheimer's disease (AD) is characterized by cognitive decline, amyloid-β accumulation, lipid dysregulation, and neuroinflammation.
- Drosophila and mouse models expressing humanized AppNLG and Aβ42 showed locomotor deficits, memory impairments, lipid accumulation, and neuroinflammation.
- Diacylglycerol O-acyltransferase 2 (Dgat2), a key enzyme in triglyceride synthesis, was identified as a modulator of AD-related phenotypes.
- Knockdown of Dgat2 in Drosophila attenuated lipid accumulation, restored synaptic integrity, and improved cognitive and locomotor deficits.
- Dgat2 suppression also improved sleep and circadian behavior, highlighting its protective effects.
- The findings suggest a link between amyloid pathology, lipid dysregulation, and neuroinflammation in AD.
- Targeting Dgat2 may represent a novel therapeutic strategy for AD.