CR1(+) tumor-associated macrophages orchestrate an immunosuppressive niche in hepatocellular carcinoma: a genetic and multi-omics dissection - PubMed
4 hours ago
- #tumor-associated macrophages
- #hepatocellular carcinoma
- #immunosuppression
- CR1+ tumor-associated macrophages (TAMs) drive an immunosuppressive microenvironment in hepatocellular carcinoma (HCC).
- Mendelian randomization links genetically predicted CR1 levels to increased HCC risk, with metabolites as potential mediators.
- CR1 is enriched in TAMs, co-localizes with M2 marker CD206, and correlates with reduced CD8+ T-cell infiltration and exhaustion.
- High CR1 in clinical samples associates with M2 macrophage accumulation, advanced disease, and poorer patient survival.
- CR1 overexpression in macrophages promotes M2 polarization, phagocytosis, PD-L1 expression, and suppression of CD8+ T-cell function.
- The study identifies CR1 as a candidate biomarker and therapeutic target for macrophage reprogramming in HCC immunotherapy.