Molecular Characterization of KLK2 RNA Expression in Prostate Cancer - PubMed
14 hours ago
- #KLK2
- #RNA expression
- #prostate cancer
- KLK2 is an androgen-regulated gene important in prostate cancer biology, with therapies targeting it in development.
- Study analyzed KLK2 RNA expression in 7,078 prostate cancer specimens, defining high/low expression as ≥75th/<25th percentiles.
- KLK2 expression was highest in adenocarcinoma and minimal in neuroendocrine prostate cancer.
- Expression was higher in androgen deprivation therapy (ADT)/androgen receptor pathway inhibitor (ARPI)-sensitive tumors compared to ADT/ARPI-exposed tumors.
- Localized tumors had higher KLK2 expression than lymph node or distant metastases, with visceral metastases showing the lowest levels.
- KLK2 expression correlated positively with androgen receptor signaling and negatively with neuroendocrine signaling.
- High KLK2 expression was associated with improved overall survival (93.9 vs. 74.4 months).
- Findings provide a molecular framework for KLK2 as a therapeutic target in prostate cancer.