Distinct amino acid metabolic subtypes predict prognosis and stratify treatment response in acute-on-chronic liver failure: a multicenter prospective study - PubMed
6 hours ago
- #ACLF prognosis
- #artificial liver support
- #amino acid metabolism
- Amino acid metabolic subtypes predict prognosis and treatment response in ACLF.
- Two subtypes (Cluster 1 and 2) identified; Cluster 2 has higher 90-day mortality.
- Cluster 2 shows severe amino acid reprogramming, especially in BCAA and glutamine pathways.
- ALS therapy response varies by subtype, with weaker survival association in Cluster 2.
- Baseline metabolic profiling can stratify patients for personalized ALS treatment strategies.