Acsl1-Mediated Fatty Acid Synthesis Impairs Osseointegration in Type 1 Diabetes - PubMed
5 hours ago
- #metabolic reprogramming
- #trained immunity
- #diabetes bone loss
- Diabetes mellitus, especially type 1 diabetes, impairs osseointegration (bone integration with implants) despite glycemic control.
- Trained immunity in macrophages, involving epigenetic memory from prior hyperglycemia, drives persistent fatty acid synthesis via Acsl1.
- H3K4me1 modification at the Acsl1 locus enhances chromatin accessibility and sustains Acsl1 transcription, promoting fatty acid anabolism.
- This metabolic reprogramming amplifies proinflammatory cytokine production and osteoclastogenesis, leading to bone damage and poor osseous repair.
- Targeting H3K4me1 or Acsl1 may improve implant osseointegration and skeletal regeneration in diabetic patients.