Endothelial cell senescence shapes T cell activity in late-stage of chronic obstructive pulmonary disease - PubMed
5 hours ago
- #Endothelial senescence
- #COPD
- #IL6 signaling
- Chronic obstructive pulmonary disease (COPD) is a leading cause of death with limited effective therapies.
- Recent studies show COPD progression involves distinct cellular and immune pathway reprogramming, not just increased inflammation.
- Severe COPD is characterized by endothelial cell senescence, marked by elevated IL6 expression.
- Endothelial-derived IL6 correlates with reduced Th1 cell abundance and impaired interferon-γ signaling, suppressing Th1-mediated immunity.
- Endothelial senescence-driven IL6 signaling is identified as a key pathogenic mechanism in late-stage COPD, suggesting a potential therapeutic target.