Maintaining and regaining episodic memory in Alzheimer disease: a circuit-based perspective - PubMed
6 hours ago
- #Alzheimer's disease
- #neural circuits
- #episodic memory
- Episodic memory loss is a key feature of Alzheimer's disease (AD), linked to the spread of AD pathology in brain circuits.
- The circuit utilization framework proposes optimizing neural resource use to improve episodic memory function in AD.
- This framework addresses synaptic dysfunction, maladaptive responses, and deficient adaptive plasticity to mitigate memory impairment.
- Strategies include reducing hypoactive and hyperactive synaptic dysfunction, minimizing maladaptive processes, and enhancing brain and cognitive reserve.
- The framework aims to complement disease-modifying treatments like anti-amyloid antibody therapies by supporting episodic memory in AD patients.