Omission of axillary surgery in early breast cancer with negative lymph nodes: a systematic review and meta-analysis of randomized clinical trials - PubMed
5 hours ago
- #Axillary Surgery
- #Meta-Analysis
- #Breast Cancer
- Omission of axillary surgery in early-stage breast cancer with clinically negative lymph nodes does not negatively impact overall survival (OS) or disease-free survival (DFS).
- A systematic review and meta-analysis of 7 randomized clinical trials (RCTs) involving 8806 patients was conducted.
- No significant differences were found in OS (OR = 1.02; 95% CI, 0.86-1.20; p = 0.84) or DFS (OR = 0.80; 95% CI, 0.63-1.00; p = 0.05) between patients who underwent no axillary surgery and those who received standard axillary interventions.
- Axillary recurrence (AR) was significantly lower in the axillary surgery group (OR = 0.18; 95% CI, 0.10-0.31; p < 0.01).
- The study followed PRISMA guidelines and was registered in PROSPERO (CRD420250653779).