Association between exposure to non-steroidal anti-inflammatory drugs in pregnancy and miscarriage risk: a French nationwide retrospective cohort study - PubMed
5 hours ago
- #Miscarriage
- #Pregnancy
- #NSAIDs
- Study evaluates the association between NSAID exposure during pregnancy and miscarriage risk.
- Data from the French National Mother-Child Register (EPI-MERES) covering 4,857,907 pregnancies (2013-2019).
- 349,294 pregnancies (7.19%) were exposed to NSAIDs from 2 weeks before conception to the 20th week.
- 163,666 miscarriage cases (3.37%) observed; NSAID exposure increased miscarriage risk (HR, 1.83; 95% CI 1.81-1.86).
- Risk varied by drug; flurbiprofen had the highest risk (HR, 3.28), naproxen the lowest (HR, 1.09).
- Sensitivity analyses showed risk remained significant but decreased with longer lag times.
- Conclusion: Early NSAID exposure may increase miscarriage risk, informing future safety recommendations.