Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration - PubMed
5 hours ago
- #Regeneration
- #HIF1A
- #Oxygen Sensing
- Mouse embryonic limbs show improved wound healing and regenerative potential when exposed to low oxygen or stabilized HIF1A.
- Xenopus tadpole limbs naturally maintain regenerative features even in high oxygen environments due to reduced oxygen-sensing capacity.
- Species-specific differences in oxygen sensing (via HIF1A regulation) are key to unlocking latent regenerative programs in mammals.